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    * Hematology101 SEARCH *

       *Filter: "Pancreas"

      

    Pancreas: Function, Location, Anatomy & Living Without One
    Your pancreas is a large gland in the back of your belly. It releases enzymes to help with digestion and hormones to regulate blood sugar.

    Pancreas - Wikipedia
    The word pancreas comes from the Greek πᾶν (pân, "all") & κρέας (kréas, "flesh"). The function of the pancreas in diabetes has been known since at least 1889, with its role in insulin production identified in 1921.

    Pancreatitis: Symptoms, Causes, Diagnosis, Treatments, Tests
    Pancreatitis is inflammation in the pancreas. Learn more from WebMD about pancreatitis, including causes, symptoms, diagnosis, treatments, risk factors, and prevention.

    5 Subtle Signs of Pancreas Problems Doctors Say You Should Know
    The top signs of pancreas problems are easy to mistake for other conditions. Here, experts share what you need to watch for and when to give your doctor a call.

    Pancreas: Functions and disorders - Medical News Today
    The pancreas is a large gland that plays a vital role in the digestive system. It secretes enzymes that help break down food and produces insulin, which is vital for managing blood sugar.

    Pancreatitis - Symptoms and causes - Mayo Clinic
    Pancreatitis is inflammation of the pancreas. Inflammation is the body's natural immune response to injury or irritation. It can lead to swelling, pain, and changes in how the pancreas works. The pancreas is a long, flat gland that's tucked behind the stomach. The pancreas helps the body digest food and regulates blood sugar.

    Pancreas Functions, Location & Disease | Columbia Surgery
    Discover the pancreas's vital roles in digestion and blood sugar regulation. Learn about its location, functions, and common diseases affecting this essential organ.

    What Does Your Pancreas Do and How to Keep It Healthy
    Your pancreas is a digestive and blood sugar regulation organ that performs two essential jobs: it produces enzymes that break down the food you eat, and it releases hormones that keep your blood sugar stable.

    Pancreas | Endocrine & Exocrine Functions | Britannica
    Pancreas, compound gland that discharges digestive enzymes into the gut and secretes the hormones insulin and glucagon, vital in carbohydrate (sugar) metabolism, into the bloodstream.

    What is the Pancreas? - Pancreatic Cancer Action Network
    The pancreas is a gland located in the abdomen with two key functions: digestion and blood sugar regulation. Learn more about your pancreas.

     

     

     

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    Hematology Symptoms
    • Fatigue and Weakness: Persistent lack of energy caused by anemia, where reduced red blood cell levels limit oxygen delivery to body tissues.
    • Unexplained Bruising and Petechiae: Easy bruising or pinpoint red spots on the skin resulting from low platelet counts or impaired blood clotting mechanisms.
    • Frequent or Recurrent Infections: Increased susceptibility to illness due to leukopenia or dysfunctional white blood cells failing to protect against pathogens.
    • Swollen Lymph Nodes: Painless enlargement of lymph glands in the neck, armpits, or groin often associated with hematologic malignancies like lymphoma or leukemia.
    • Unexplained Fever and Night Sweats: Systemic symptoms frequently tied to active hematologic disorders or hypermetabolic states driven by bone marrow dysfunction.
    • Shortness of Breath and Palpitations: Respiratory distress or rapid heart rate during light activity as the cardiovascular system attempts to compensate for severe anemia.
    • Bone or Joint Pain: Deep, aching discomfort caused by the expansion of abnormal blood cells within the bone marrow space.

      

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    Hematology History
    • 1658: Discovery of Red Blood Cells Jan Swammerdam becomes the first person to observe red blood cells under a microscope in frog blood, followed closely by Antonie van Leeuwenhoek in human blood.
    • 1901: Discovery of ABO Blood Groups Karl Landsteiner identifies the A, B, and O blood groups, laying the scientific foundation for safe blood transfusions and earning the Nobel Prize.
    • 1910: First Description of Sickle Cell Anemia James B. Herrick publishes the first detailed medical account of elongated, sickle-shaped red blood cells in a dental student from Grenada.
    • 1940: Identification of the Rh Factor Karl Landsteiner and Alexander Wiener discover the Rh factor, drastically reducing fatal transfusion reactions and resolving hemolytic disease of the newborn.
    • 1948: First Remission of Childhood Leukemia Sidney Farber demonstrates that aminopterin (a folic acid antagonist) can achieve temporary remissions in acute lymphoblastic leukemia, marking the birth of modern cancer chemotherapy.
    • 1957: First Successful Human Bone Marrow Transplant E. Donnall Thomas performs the first successful intravenous infusion of bone marrow stem cells into leukemia patients treated with radiation therapy.
    • 1960: Discovery of the Philadelphia Chromosome Peter Nowell and David Hungerford identify a specific chromosomal abnormality in chronic myeloid leukemia, establishing the genetic basis of cancer.
    Current Hematology Research
    • Gene Therapy for Sickle Cell Disease: Advances in CRISPR-based gene editing are enabling targeted modifications in patient hematopoietic stem cells to restore healthy hemoglobin production.
    • CAR-T Cell Innovations in Hematologic Malignancies: Next-generation chimeric antigen receptor T-cell therapies are expanding target antigens to overcome resistance mechanisms in relapsed leukemia and lymphoma.
    • Minimal Residual Disease (MRD) Tracking: High-throughput sequencing and digital PCR techniques are improving early detection of residual cancer cells to guide personalized treatment timelines.
    • Bispecific Antibodies in Multiple Myeloma: Dual-targeting immunotherapies are showing high response rates by simultaneously binding to tumor antigens and cytotoxic T cells to induce targeted lysis.
    • Novel Factor VIII Mimetic Agents for Hemophilia: Long-acting subcutaneous non-factor replacement therapies continue to lower bleeding rates and reduce the burden of frequent intravenous infusions.
    • JAK Inhibitors in Myelofibrosis: Targeted kinase inhibition therapies are demonstrating significant efficacy in reducing splenomegaly and improving constitutional symptoms in chronic myeloproliferative neoplasms.
    • Complement System Targeted Therapies in PNH: Next-generation C3 and C5 complement inhibitors offer improved control over extravascular hemolysis in paroxysmal nocturnal hemoglobinuria.

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