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    * Hematology101 SEARCH *

       *Filter: "Liver"

      

    Liver: Where It’s Located, Function & Anatomy
    Your liver is located on the right side of your upper abdomen. Its functions include filtering blood, making chemicals and fighting infections.

    Liver - Wikipedia
    The diagnosis of liver disease is made by liver function tests, groups of blood tests, that can readily show the extent of liver damage. If infection is suspected, then other serological tests will be carried out.

    Liver Disease: Symptoms, Causes, Stages & Treatment
    Liver disease includes many conditions that can damage your liver and affect how it works. Some are mild, while others can be serious or long-lasting. Because your liver plays such an important role in your body, damage can affect your overall health. Knowing what to watch for and getting early care can make a big difference. Contents

    Liver problems - Symptoms and causes - Mayo Clinic
    The liver has a lot of vital tasks including ridding the body of toxins. Learn about problems that can affect the liver and how to avoid them.

    Liver | Functions, Diseases & Treatments | Britannica
    liver, the largest gland in the body, a spongy mass of wedge-shaped lobes that has many metabolic and secretory functions.

    Liver: Anatomy and Functions - Johns Hopkins Medicine
    All the blood leaving the stomach and intestines passes through the liver. The liver processes this blood and breaks down, balances, and creates the nutrients and also metabolizes drugs into forms that are easier to use for the rest of the body or that are nontoxic.

    Liver Functions, Location, Anatomy and Disease | Columbia Surgery
    It is located beneath the rib cage in the right upper abdomen. The liver filters all of the blood in the body and breaks down poisonous substances, such as alcohol and drugs. The liver also produces bile, a fluid that helps digest fats and carry away waste.

    Liver Anatomy and Function Tests, Disease Signs, Pain Causes
    Get information about the function of the liver, the largest gland in the body. Liver diseases include hepatitis, cancer of the liver, infections, medications, genetic conditions, and blood flow problems.

    Liver disease - Wikipedia
    Liver diseases, including conditions such as non-alcoholic fatty liver disease (NAFLD), alcohol-related liver disease (ALD), and viral hepatitis, are significant public health concerns worldwide.

    Liver Failure: Causes, Symptoms, Treatments, Tests & More - WebMD
    You often don't realize you have liver damage until several years have passed. Each time the liver has to repair itself because of injury from one of these conditions, it forms scar tissue.

     

     

     

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    Hematology Symptoms
    • Fatigue and Weakness: Persistent lack of energy caused by anemia, where reduced red blood cell levels limit oxygen delivery to body tissues.
    • Unexplained Bruising and Petechiae: Easy bruising or pinpoint red spots on the skin resulting from low platelet counts or impaired blood clotting mechanisms.
    • Frequent or Recurrent Infections: Increased susceptibility to illness due to leukopenia or dysfunctional white blood cells failing to protect against pathogens.
    • Swollen Lymph Nodes: Painless enlargement of lymph glands in the neck, armpits, or groin often associated with hematologic malignancies like lymphoma or leukemia.
    • Unexplained Fever and Night Sweats: Systemic symptoms frequently tied to active hematologic disorders or hypermetabolic states driven by bone marrow dysfunction.
    • Shortness of Breath and Palpitations: Respiratory distress or rapid heart rate during light activity as the cardiovascular system attempts to compensate for severe anemia.
    • Bone or Joint Pain: Deep, aching discomfort caused by the expansion of abnormal blood cells within the bone marrow space.

      

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    Hematology History
    • 1658: Discovery of Red Blood Cells Jan Swammerdam becomes the first person to observe red blood cells under a microscope in frog blood, followed closely by Antonie van Leeuwenhoek in human blood.
    • 1901: Discovery of ABO Blood Groups Karl Landsteiner identifies the A, B, and O blood groups, laying the scientific foundation for safe blood transfusions and earning the Nobel Prize.
    • 1910: First Description of Sickle Cell Anemia James B. Herrick publishes the first detailed medical account of elongated, sickle-shaped red blood cells in a dental student from Grenada.
    • 1940: Identification of the Rh Factor Karl Landsteiner and Alexander Wiener discover the Rh factor, drastically reducing fatal transfusion reactions and resolving hemolytic disease of the newborn.
    • 1948: First Remission of Childhood Leukemia Sidney Farber demonstrates that aminopterin (a folic acid antagonist) can achieve temporary remissions in acute lymphoblastic leukemia, marking the birth of modern cancer chemotherapy.
    • 1957: First Successful Human Bone Marrow Transplant E. Donnall Thomas performs the first successful intravenous infusion of bone marrow stem cells into leukemia patients treated with radiation therapy.
    • 1960: Discovery of the Philadelphia Chromosome Peter Nowell and David Hungerford identify a specific chromosomal abnormality in chronic myeloid leukemia, establishing the genetic basis of cancer.
    Current Hematology Research
    • Gene Therapy for Sickle Cell Disease: Advances in CRISPR-based gene editing are enabling targeted modifications in patient hematopoietic stem cells to restore healthy hemoglobin production.
    • CAR-T Cell Innovations in Hematologic Malignancies: Next-generation chimeric antigen receptor T-cell therapies are expanding target antigens to overcome resistance mechanisms in relapsed leukemia and lymphoma.
    • Minimal Residual Disease (MRD) Tracking: High-throughput sequencing and digital PCR techniques are improving early detection of residual cancer cells to guide personalized treatment timelines.
    • Bispecific Antibodies in Multiple Myeloma: Dual-targeting immunotherapies are showing high response rates by simultaneously binding to tumor antigens and cytotoxic T cells to induce targeted lysis.
    • Novel Factor VIII Mimetic Agents for Hemophilia: Long-acting subcutaneous non-factor replacement therapies continue to lower bleeding rates and reduce the burden of frequent intravenous infusions.
    • JAK Inhibitors in Myelofibrosis: Targeted kinase inhibition therapies are demonstrating significant efficacy in reducing splenomegaly and improving constitutional symptoms in chronic myeloproliferative neoplasms.
    • Complement System Targeted Therapies in PNH: Next-generation C3 and C5 complement inhibitors offer improved control over extravascular hemolysis in paroxysmal nocturnal hemoglobinuria.

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