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       *Filter: "Jaundice"

      

    Adult Jaundice: What It Is, Symptoms, Causes & Treatment
    Jaundice is a condition where your skin, the whites of your eyes and mucous membranes (like the inside of your nose and mouth) turn yellow. Many medical conditions can cause jaundice, like hepatitis, gallstones and tumors.

    Jaundice - Wikipedia
    Hepatic jaundice (hepatocellular jaundice) is due to significant disruption of liver function, leading to hepatic cell death and necrosis and impaired bilirubin transport across hepatocytes.

    Jaundice: Causes, Symptoms, and Treatment Options - WebMD
    Jaundice is a condition that causes yellowing of the skin and eyes. Learn about the causes, symptoms, and treatment options for jaundice in this comprehensive guide.

    Jaundice: Causes, symptoms, and treatments - Medical News Today
    This article discusses what causes jaundice, how healthcare professionals diagnose and treat the condition, and how a person can help to prevent it from occurring.

    Infant jaundice - Symptoms & causes - Mayo Clinic
    Excess bilirubin, called hyperbilirubinemia, is the main cause of jaundice. Bilirubin is a yellow-pigmented substance released into the bloodstream when red blood cells break down.

    Jaundice Symptoms, Causes, Diagnosis, and Treatment - Health
    Symptoms of jaundice include itchy skin, clay-colored stools, and unintentional weight loss. Jaundice can happen from conditions that affect your blood, liver, or bile ducts.

    Jaundice: Causes, Symptoms, Types and Treatment Options
    Jaundice causes yellowing of the skin and eyes. Learn about Jaundice causes, early symptoms, and treatment options to manage liver-related health issues.

    Jaundice - NHS
    Jaundice is when your skin or the whites of your eyes turn yellow. It can be a sign of something serious, such as liver disease, so you need to get urgent medical help.

    Jaundice in Adults - Liver and Gallbladder Disorders - Merck Manual ...
    In jaundice, the skin and whites of the eyes look yellow. Jaundice occurs when there is too much bilirubin (a yellow pigment) in the blood—a condition called hyperbilirubinemia.

    Jaundice | Icterus | MedlinePlus
    Jaundice is a yellow coloring of the skin or eyes caused by too much bilirubin in the body. Jaundice can happen for many reasons. Learn about it here.

     

     

     

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    Hematology Symptoms
    • Fatigue and Weakness: Persistent lack of energy caused by anemia, where reduced red blood cell levels limit oxygen delivery to body tissues.
    • Unexplained Bruising and Petechiae: Easy bruising or pinpoint red spots on the skin resulting from low platelet counts or impaired blood clotting mechanisms.
    • Frequent or Recurrent Infections: Increased susceptibility to illness due to leukopenia or dysfunctional white blood cells failing to protect against pathogens.
    • Swollen Lymph Nodes: Painless enlargement of lymph glands in the neck, armpits, or groin often associated with hematologic malignancies like lymphoma or leukemia.
    • Unexplained Fever and Night Sweats: Systemic symptoms frequently tied to active hematologic disorders or hypermetabolic states driven by bone marrow dysfunction.
    • Shortness of Breath and Palpitations: Respiratory distress or rapid heart rate during light activity as the cardiovascular system attempts to compensate for severe anemia.
    • Bone or Joint Pain: Deep, aching discomfort caused by the expansion of abnormal blood cells within the bone marrow space.

      

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    Hematology History
    • 1658: Discovery of Red Blood Cells Jan Swammerdam becomes the first person to observe red blood cells under a microscope in frog blood, followed closely by Antonie van Leeuwenhoek in human blood.
    • 1901: Discovery of ABO Blood Groups Karl Landsteiner identifies the A, B, and O blood groups, laying the scientific foundation for safe blood transfusions and earning the Nobel Prize.
    • 1910: First Description of Sickle Cell Anemia James B. Herrick publishes the first detailed medical account of elongated, sickle-shaped red blood cells in a dental student from Grenada.
    • 1940: Identification of the Rh Factor Karl Landsteiner and Alexander Wiener discover the Rh factor, drastically reducing fatal transfusion reactions and resolving hemolytic disease of the newborn.
    • 1948: First Remission of Childhood Leukemia Sidney Farber demonstrates that aminopterin (a folic acid antagonist) can achieve temporary remissions in acute lymphoblastic leukemia, marking the birth of modern cancer chemotherapy.
    • 1957: First Successful Human Bone Marrow Transplant E. Donnall Thomas performs the first successful intravenous infusion of bone marrow stem cells into leukemia patients treated with radiation therapy.
    • 1960: Discovery of the Philadelphia Chromosome Peter Nowell and David Hungerford identify a specific chromosomal abnormality in chronic myeloid leukemia, establishing the genetic basis of cancer.
    Current Hematology Research
    • Gene Therapy for Sickle Cell Disease: Advances in CRISPR-based gene editing are enabling targeted modifications in patient hematopoietic stem cells to restore healthy hemoglobin production.
    • CAR-T Cell Innovations in Hematologic Malignancies: Next-generation chimeric antigen receptor T-cell therapies are expanding target antigens to overcome resistance mechanisms in relapsed leukemia and lymphoma.
    • Minimal Residual Disease (MRD) Tracking: High-throughput sequencing and digital PCR techniques are improving early detection of residual cancer cells to guide personalized treatment timelines.
    • Bispecific Antibodies in Multiple Myeloma: Dual-targeting immunotherapies are showing high response rates by simultaneously binding to tumor antigens and cytotoxic T cells to induce targeted lysis.
    • Novel Factor VIII Mimetic Agents for Hemophilia: Long-acting subcutaneous non-factor replacement therapies continue to lower bleeding rates and reduce the burden of frequent intravenous infusions.
    • JAK Inhibitors in Myelofibrosis: Targeted kinase inhibition therapies are demonstrating significant efficacy in reducing splenomegaly and improving constitutional symptoms in chronic myeloproliferative neoplasms.
    • Complement System Targeted Therapies in PNH: Next-generation C3 and C5 complement inhibitors offer improved control over extravascular hemolysis in paroxysmal nocturnal hemoglobinuria.

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