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    * Hematology101 SEARCH *

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    Blood - Wikipedia
    Blood is a body fluid in the circulatory system of humans and other vertebrates that delivers necessary substances such as nutrients and oxygen to the cells of the body, and transports metabolic waste products away from those same cells. [1] Blood is composed of blood cells suspended in plasma.

    Blood | American Society of Hematology
    In this week's episode, Blood editor Dr. Laurie Sehn interviews Drs. Camille Laurent and Christine Bezombeson on their latest article published in Blood titled " Patient-derived lymphoma spheroids reveal predictive markers of glofitamab resistance in relapsed/refractory B-NHL."

    Blood: What It Is & Function - Cleveland Clinic
    Blood is a specialized fluid that constantly flows throughout your body. It’s made of plasma, red blood cells, white blood cells and platelets.

    Blood | Definition, Composition, Functions, & Facts | Britannica
    Blood is a fluid that transports oxygen and nutrients to cells and carries away carbon dioxide and other waste products. It contains specialized cells that serve particular functions. These cells are suspended in a liquid matrix known as plasma.

    Blood Basics - Hematology.org
    It has four main components: plasma, red blood cells, white blood cells, and platelets. The blood that runs through the veins, arteries, and capillaries is known as whole blood—a mixture of about 55% plasma and 45% blood cells. About 7% to 8% of your total body weight is blood.

    Blood - Simple English Wikipedia, the free encyclopedia
    5Gold in human blood. 6Where blood comes from. 7References. Toggle the table of contents. Blood. 211 languages. Afrikaans. Alemannisch. አማርኛ. Pangcah.

    Blood - MedlinePlus
    The solid part of your blood contains red blood cells, white blood cells, and platelets. Red blood cells (RBC) deliver oxygen from your lungs to your tissues and organs.

    Blood: Components, Formation, Functions, Circulation
    Blood is a liquid connective tissue made up of blood cells and plasma that circulate inside the blood vessels under the pumping action of the heart.

    Facts About Blood - Johns Hopkins Medicine
    Detailed information on blood, including components of blood, functions of blood cells and common blood tests.

    Blood cell - Wikipedia
    A blood cell (also called a hemocyte or hematocyte) is a cell produced through hematopoiesis and found mainly in the blood. Major types of blood cells include red blood cells (erythrocytes), white blood cells (leukocytes), and platelets (thrombocytes).

     

     

     

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    Hematology Symptoms
    • Fatigue and Weakness: Persistent lack of energy caused by anemia, where reduced red blood cell levels limit oxygen delivery to body tissues.
    • Unexplained Bruising and Petechiae: Easy bruising or pinpoint red spots on the skin resulting from low platelet counts or impaired blood clotting mechanisms.
    • Frequent or Recurrent Infections: Increased susceptibility to illness due to leukopenia or dysfunctional white blood cells failing to protect against pathogens.
    • Swollen Lymph Nodes: Painless enlargement of lymph glands in the neck, armpits, or groin often associated with hematologic malignancies like lymphoma or leukemia.
    • Unexplained Fever and Night Sweats: Systemic symptoms frequently tied to active hematologic disorders or hypermetabolic states driven by bone marrow dysfunction.
    • Shortness of Breath and Palpitations: Respiratory distress or rapid heart rate during light activity as the cardiovascular system attempts to compensate for severe anemia.
    • Bone or Joint Pain: Deep, aching discomfort caused by the expansion of abnormal blood cells within the bone marrow space.

      

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    Hematology History
    • 1658: Discovery of Red Blood Cells Jan Swammerdam becomes the first person to observe red blood cells under a microscope in frog blood, followed closely by Antonie van Leeuwenhoek in human blood.
    • 1901: Discovery of ABO Blood Groups Karl Landsteiner identifies the A, B, and O blood groups, laying the scientific foundation for safe blood transfusions and earning the Nobel Prize.
    • 1910: First Description of Sickle Cell Anemia James B. Herrick publishes the first detailed medical account of elongated, sickle-shaped red blood cells in a dental student from Grenada.
    • 1940: Identification of the Rh Factor Karl Landsteiner and Alexander Wiener discover the Rh factor, drastically reducing fatal transfusion reactions and resolving hemolytic disease of the newborn.
    • 1948: First Remission of Childhood Leukemia Sidney Farber demonstrates that aminopterin (a folic acid antagonist) can achieve temporary remissions in acute lymphoblastic leukemia, marking the birth of modern cancer chemotherapy.
    • 1957: First Successful Human Bone Marrow Transplant E. Donnall Thomas performs the first successful intravenous infusion of bone marrow stem cells into leukemia patients treated with radiation therapy.
    • 1960: Discovery of the Philadelphia Chromosome Peter Nowell and David Hungerford identify a specific chromosomal abnormality in chronic myeloid leukemia, establishing the genetic basis of cancer.
    Current Hematology Research
    • Gene Therapy for Sickle Cell Disease: Advances in CRISPR-based gene editing are enabling targeted modifications in patient hematopoietic stem cells to restore healthy hemoglobin production.
    • CAR-T Cell Innovations in Hematologic Malignancies: Next-generation chimeric antigen receptor T-cell therapies are expanding target antigens to overcome resistance mechanisms in relapsed leukemia and lymphoma.
    • Minimal Residual Disease (MRD) Tracking: High-throughput sequencing and digital PCR techniques are improving early detection of residual cancer cells to guide personalized treatment timelines.
    • Bispecific Antibodies in Multiple Myeloma: Dual-targeting immunotherapies are showing high response rates by simultaneously binding to tumor antigens and cytotoxic T cells to induce targeted lysis.
    • Novel Factor VIII Mimetic Agents for Hemophilia: Long-acting subcutaneous non-factor replacement therapies continue to lower bleeding rates and reduce the burden of frequent intravenous infusions.
    • JAK Inhibitors in Myelofibrosis: Targeted kinase inhibition therapies are demonstrating significant efficacy in reducing splenomegaly and improving constitutional symptoms in chronic myeloproliferative neoplasms.
    • Complement System Targeted Therapies in PNH: Next-generation C3 and C5 complement inhibitors offer improved control over extravascular hemolysis in paroxysmal nocturnal hemoglobinuria.

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